Akutna plućna insuficijencija; respiratorna depresija, akutna ili hronična teška respiratorna insuficijencija (insuficijencija ventilacije se može pogoršati);
Oni mogu biti udruženi sa drugim neželjenim reakcijama uključujući promene raspoloženja, anksioznost ili poremećaje spavanja i uznemirenost. S obzirom na
Hronična upotreba kortikosteroida ubrzava metabolizam diazepama tako što indukuje izoenzim CYP3A4 citohroma P450 ili enzime odgovorne za glukuronidaciju. Smanjeno dejstvo diazepama.
Kod oštećene funkcije bubrega ne dolazi do klinički značajne promene u poluvremenu eliminacije diazepama, tako da obično nije neophodno prilagođavanje doze.
Codeine is remodeled to morphine from the liver by an enzyme. Morphine could be the substance that produces ache relief. Some individuals have a variation of the enzyme and this can have an impact on folks in other ways. In many people, morphine will not be made or manufactured in extremely smaller quantities, and it'll not give adequate agony aid.
In case you are Expecting or breast-feeding, Believe you may be Expecting or are intending to Have a very newborn, question your health practitioner or pharmacist for information ahead of using this medicine.
An case in point could be the popular blend of pre-surgical procedures stress and the necessity for pre-anesthesia sedation, equally of which might be treatable bensedin diazepam with benzodiazepines like diazepam or midazolam.
The quantity of paracetamol within the 4 various strengths is similar (500 mg), but the quantity of dihydrocodeine differs which decides the strength in the preparing.
Antivirusni lekovi inhibiraju CYP3A4 metabolički put diazepama. Povećan je rizik od sedacije i respiratorne depresije. Zbog toga treba izbegavati istovremenu primenu.
Ovakav rastvor dobro promućkati pre upotrebe i koristiti jednokratno. Postoje dokazi da se diazepam adsorbuje na plastiku u infuzionim kesama i setovima za infuziju. Stoga se preporučuje da se koriste staklene boce prilikom primene diazepama intravenskom infuzijom.
Posebne mere opreza pri odlaganju materijala koji treba odbaciti nakon primene leka (i druga uputstva za rukovanje lekom)
Your Health care company will probably advise that you simply don’t function or drive ideal right after you start using benzodiazepines. You may be able to work or push soon after you start having them, based on how these medications influence you, the dose you are taking, just how long the medication past along with other factors.
When you are having almost every other medicines. This involves here any medicines you might be using which are available to order and not using a prescription, and also herbal and complementary medicines.
Ovaj efekat vidljiv je kod CYP2C19 brzih metabolizera, ali ne i kod sporih metabolizera, sa manjim klirensom diazepama. Pojačano je dejstvo diazepama. Možda će biti neophodno smanjenje doze diazepama.